Anti-Human CD35 Reference Antibody (Ledacocept, RUO) (HB625016)

Name: Anti-Human CD35 Reference Antibody (Ledacocept, RUO)
Brand: abinScience
SKU: HB625016
Price: 370 USD
Availability: InStock

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100ug
1mg

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Numéro de catalogue	HB625016
Description	Anti-Human CD35 Reference Antibody (Ledacocept, RUO) (HB625016) is a monoclonal antibody detecting CD35.
Reactivité des espèces	Human
Applications	ELISA, FCM, Functional assay
Clonalité	Monoclonal
Isotype	CD35
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	C3BR, C3b/C4b receptor, CD35, CR1, Complement receptor type 1
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P17927
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Noms alternatifs	CAS: 3083227-23-7
Contexte	Complement receptor type 1 (CD35/CR1) is a ~223 kDa protein. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. 1. Schifferli, JA. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 140, 899-904. PMID: 2963069 2. Klickstein, LB. et al. (1988) The Journal of experimental medicine 168, 1699-717. PMID: 2972794 3. Krych, M. et al. (1994) The Journal of biological chemistry 269, 13273-8. PMID: 8175757 4. Török, K. et al. (2015) Immunology letters 164, 117-24. PMID: 25742728
Note	For research use only. Not suitable for clinical or therapeutic use.

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Anti-Human CD35 Reference Antibody (Ledacocept, RUO).pdf

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Anti-Human CD35 Reference Antibody (Ledacocept, RUO) (HB625016)

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