

| Каталожный номер | HB651346 | ||||
|---|---|---|---|---|---|
| Описание |
Anti-Human CTLA-4 Reference Antibody (Ipilimumab, RUO) (HB651346) is a mouse monoclonal antibody detecting CTLA-4 in ELISA, FCM, Functional assay. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||
| Применения | ELISA, FCM, Functional assay | ||||
| Хозяинский вид | Mouse | ||||
| Клоональность | Monoclonal | ||||
| Изотип | IgG1, kappa | ||||
| ID клона | Ipilimumab | ||||
| Система экспрессии | Mammalian cells | ||||
| Характер | Recombinant | ||||
| Цель | CD152, CTLA-4, CTLA4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4 | ||||
| Уровень эндотоксинов | < 10 EU/mg as determined by LAL method. | ||||
| Чистота | >95% as determined by SDS-PAGE. | ||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||
| Номер доступа | P16410 | ||||
| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Фон | Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy). 1. Schwartz, JC. et al. (2001) Nature 410, 604-8. PMID: 11279501 2. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502 3. Teft, WA. et al. (2006) Annual review of immunology 24, 65-97. PMID: 16551244 4. Linsley, PS. et al. (1991) The Journal of experimental medicine 174, 561-9. PMID: 1714933 5. Zheng, Y. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1683-91. PMID: 18641304 6. Ramagopal, UA. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E4223-E4232. PMID: 28484017 | ||||
| Примечание | For research use only. Not suitable for clinical or therapeutic use. |




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