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| カタログ番号 | HB735023 |
|---|---|
| 説明 |
Anti-Human CD46 Recombinant Antibody (SRR0011) (HB735023) is a rabbit monoclonal antibody detecting CD46 in FCM, WB. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | FCM, WB |
| 宿主種 | Rabbit |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | SRR0011 |
| テスト済みアプリケーション | FCM, WB |
| ターゲット | CD46, MCP, MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen |
| エンドトキシンレベル | < 10 EU/mg as determined by LAL method. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P15529 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Membrane cofactor protein (CD46) is a ~43 kDa protein. Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. |
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-CD46monoclonal antibody at 1 ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: HEK293T cell lysate
Flow-cytometry using anti-Human CD46 antibody. Jurkat cells were stained with an irrelevant antibody (Blue Histogram) or an anti-Human CD46 monoclonal antibody (Catalog HB735023, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Rabbit IgG H&L Polyclonal Antibody, FITC (abinScience:TF690414) and cells analysed on a NovoCyte Flow Cytometer.
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