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Anti-Mouse CD274/PD-L1/B7-H1 Antibody (SAA0268), FITC (MV974117)

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概要
カタログ番号MV974117
説明
Anti-Mouse CD274/PD-L1/B7-H1 Antibody (SAA0268), FITC [SAA0268] (MV974117) is a rat monoclonal antibody detecting B7-H1 in ELISA, FCM. Suitable for Mouse.
Highlights
  • Flow Cytometry — Validated for flow cytometry applications.
  • Fluorescent Label — Direct conjugate for streamlined workflows.
種反応性Mouse
アプリケーションELISA, FCM
宿主種Rat
アイソタイプIgG1, kappa
クローンIDSAA0268
抱合FITC
クローン性 Monoclonal
ターゲット B7-H1, Programmed cell death 1 ligand 1, PDCD1 ligand 1, PDCD1L1, B7 homolog 1, PDCD1LG1, PDL1, hPD-L1, Programmed death ligand 1, B7H1, PD-L1, CD274
エンドトキシンレベル Please contact with the lab for this information.
アクセッション番号 Q9EP73
形態 Liquid
保存バッファー 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

安定性と保存 Store at 4°C for 12 months. Protect from light. Do not freeze.
背景

Programmed cell death 1 ligand 1 (CD274/PD-L1) is a ~32 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). CD274 is the therapeutic target of atezolizumab (Tecentriq) and durvalumab (Imfinzi).

1. Tamura, H. et al. (2001) Blood 97, 1809-16. PMID: 11238124
2. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443
3. Wang, S. et al. (2003) The Journal of experimental medicine 197, 1083-91. PMID: 12719480
注意事項 For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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参考文献
Formula
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