Anti-Durvalumab ELISA Kit (AV974028)

概要
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参考文献
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概要

カタログ番号	AV974028
説明	Anti-Durvalumab ELISA Kit (AV974028) — Quantitative sandwich ELISA for Anti-Durvalumab. Sample: Plasma, Serum. Range: 156.25 - 10, 000 ng/mL. Highlights ●Sandwich Format — High specificity, reliable quantification. ●Ready-to-Use — Complete kit with pre-coated plates included.
アプリケーション	ELISA
アクセッション番号	Q9NZQ7
検出方法	Colorimetric
サンプルタイプ	Plasma, Serum
アッセイタイプ	Quantitative
レンジ	156.25 - 10, 000 ng/mL
回収率	80-120%
発送	2-8 ℃
安定性と保存	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
仕様	Durvalumab
別名	MEDI4736, 1428935-60-7
背景	Programmed cell death 1 ligand 1 (Durvalumab) is a ~33 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. 1. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443 2. Mezzadra, R. et al. (2017) Nature 549, 106-110. PMID: 28813410 3. Burr, ML. et al. (2017) Nature 549, 101-105. PMID: 28813417 4. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419 5. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298 6. Dong, H. et al. (1999) Nature medicine 5, 1365-9. PMID: 10581077 7. Hou, J. et al. (2020) Nature cell biology 22, 1264-1275. PMID: 32929201
注意事項	For Research Use Only.