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| カタログ番号 | VK425010 |
|---|---|
| 説明 |
InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242) [m242] (VK425010) is a human monoclonal antibody detecting Structural polyprotein in ELISA, Neutralization. Suitable for Chikungunya virus.
|
| 種反応性 | Chikungunya virus |
| アプリケーション | ELISA, Neutralization |
| 宿主種 | Human |
| アイソタイプ | IgG1 |
| クローンID | m242 |
| クローン性 | Monoclonal |
| ターゲット | Structural polyprotein, p130, Capsid protein, 3.4.21.90, Coat protein, C, Precursor of protein E3/E2, p62, pE2, Assembly protein E3, Spike glycoprotein E2, E2 envelope glycoprotein, 6K protein, Spike glycoprotein E1, E1 envelope glycoprotein |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q8JUX5, Q1H8W5, Q5XXP3 |
| RRID | InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242) (abinScience Cat# VK425010, RRID:AB_3729552) |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Structural polyprotein (VLP) is a ~138 kDa protein. Forms an icosahedral capsid with a T=4 symmetry composed of 240 copies of the capsid protein surrounded by a lipid membrane through which penetrate 80 spikes composed of trimers of E1-E2 heterodimers. The capsid protein binds to the viral RNA genome at a site adjacent to a ribosome binding site for viral genome translation following genome release. Possesses a protease activity that results in its autocatalytic cleavage from the nascent structural protein. Following its self-cleavage, the capsid protein transiently associates with ribosomes, and within several minutes the protein binds to viral RNA and rapidly assembles into icosahedric core particles. The resulting nucleocapsid eventually associates with the cytoplasmic domain of the spike glycoprotein E2 at the cell membrane, leading to budding and formation of mature virions. 1. Webb, LG. et al. (2020) PLoS pathogens 16, e1008999. PMID: 33057424 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242)
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