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| カタログ番号 | HS870086 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Humanized |
| アイソタイプ | IgG4-kappa |
| 発現システム | Mammalian Cells |
| クローン性 | Monoclonal |
| ターゲット | Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279 |
| エンドトキシンレベル | Please contact the lab for this information. |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q15116 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 別名 | 1924598-82-2 |
| 背景 | Balstilimab is a novel, fully human monoclonal immunoglobulin G4 (IgG4) designed to block PD-1 (programmed cell death protein 1) from interacting with its ligands PD-L1 and PD-L2. PD-1 is a negative regulator of immune activation that is considered a foundational target within the immuno-oncology market. • The blockade of immune checkpoints in cancer immunotherapy., PMID:22437870 • PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations., PMID:30888929 • The diverse functions of the PD1 inhibitory pathway., PMID:28990585 • PD-1/PD-L1 immune checkpoint: Potential target for cancer therapy., PMID:30191996 • Immune Checkpoint Blockade in Cancer Therapy., PMID:25605845 • PD-1 expression and clinical PD-1 blockade in B-cell lymphomas., PMID:29118007 • Overcoming T cell exhaustion in infection and cancer., PMID:25797516 • Study and analysis of antitumor resistance mechanism of PD1/PD-L1 immune checkpoint blocker., PMID:32875727 • Tumor Mutational Burden and Response Rate to PD-1 Inhibition., PMID:29262275 • PD-L1., PMID:29097600 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Toripalimab.
Detects Human CD279/PDCD1/PD1 in indirect ELISAs.
SDS-PAGE for Research Grade Toripalimab.
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