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Research Grade Cemiplimab (HS870016)

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Research Grade Cemiplimab

Research Grade Cemiplimab

Research Grade Cemiplimab

Research Grade Cemiplimab

Research Grade Cemiplimab

Research Grade Cemiplimab

価格(USD): $

スペック:

100ug
1mg

数量:

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概要
イメージ
参考文献
データシート

概要

カタログ番号	HS870016
説明	Cemiplimab (HS870016) is a research-grade recombinant antibody targeting CD1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
アイソタイプ	IgG4-kappa
発現システム	Mammalian Cells
クローン性	Monoclonal
ターゲット	Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
エンドトキシンレベル	Please contact the lab for this information.
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q15116
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
別名	REGN-2810, SAR-439684, cemiplimab-rwlc, 1801342-60-8
背景	Programmed cell death protein 1 (CD279/PD-1) is a ~31 kDa protein. Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. CD279 is the therapeutic target of pembrolizumab (Keytruda) and nivolumab (Opdivo). 1. Fife, BT. et al. (2011) Annals of the New York Academy of Sciences 1217, 45-59. PMID: 21276005 2. Bardhan, K. et al. (2019) Scientific reports 9, 17252. PMID: 31754127 3. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441 4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329 5. Zak, KM. et al. (2015) Structure (London, England : 1993) 23, 2341-2348. PMID: 26602187
注意事項	For research use only. Not suitable for clinical or therapeutic use.

イメージ

SEC-HPLC

SEC-HPLC detection for Research Grade Cemiplimab.
Bioactivity

Detects Human CD279/PDCD1/PD1 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Cemiplimab.

参考文献

データシート

Research Grade Cemiplimab.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

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Stock Solution

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Working Solution

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Research Grade Cemiplimab