

| Numéro de catalogue | VK584036 |
|---|---|
| Description |
Silevimig (VK584036) is a research-grade recombinant antibody targeting Glycoprotein. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| Reactivité des espèces | Rabies Virus (RABV) |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Espèce hôte | Human |
| Isotype | Ig(G1_L-kappa)_scFv-G1(h-CH2-CH3) |
| Système d'expression | Mammalian Cells |
| Clonalité | Monoclonal |
| Cible | Glycoprotein, G |
| Niveau d'endotoxines | Please contact the lab for this information. |
| Pureté | >95% purity as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Numéro d'accès | P03524 |
| Forme | Liquid |
| Tampon de stockage | 0.01M PBS, pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Noms alternatifs | Bispecific, 2618667-99-3 |
| Contexte | Glycoprotein is a ~58 kDa protein. Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. |
| Note | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for Research Grade Silevimig.



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