

| カタログ番号 | HV974386 |
|---|---|
| 説明 |
fetrastobart (HV974386) is a research-grade recombinant antibody targeting CD274.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, FACS, Functional assay |
| 宿主種 | Human |
| アイソタイプ | IgG1, kappa |
| ターゲット | B7-H1 / PD-L1 / CD274 |
| 純度 | >95% as determined by SDS-PAGE |
| アクセッション番号 | Q9NZQ7 |
| 保存バッファー | 0.01 M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 別名 | CAS: 3028439-63-3 |
| 背景 | Programmed cell death 1 ligand 1 is a ~33 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. 1. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443 2. Mezzadra, R. et al. (2017) Nature 549, 106-110. PMID: 28813410 3. Burr, ML. et al. (2017) Nature 549, 101-105. PMID: 28813417 4. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419 5. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298 6. Dong, H. et al. (1999) Nature medicine 5, 1365-9. PMID: 10581077 7. Hou, J. et al. (2020) Nature cell biology 22, 1264-1275. PMID: 32929201 |
| 注意事項 | For research use only. |

SDS-PAGE for Research Grade fetrastobart


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