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Research Grade fetrastobart (HV974386)

Research Grade fetrastobart
Research Grade fetrastobart
価格(USD): $
スペック:
  • 100ug
  • 1mg
数量:
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  • 概要

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  • データシート

概要
カタログ番号HV974386
説明
fetrastobart (HV974386) is a research-grade recombinant antibody targeting CD274.
Highlights
  • Research Grade — For PK/PD studies, assay development, and ADA research.
種反応性Human
アプリケーションELISA, FACS, Functional assay
宿主種Human
アイソタイプIgG1, kappa
ターゲット B7-H1 / PD-L1 / CD274
純度 >95% as determined by SDS-PAGE
アクセッション番号 Q9NZQ7
保存バッファー 0.01 M PBS pH 7.4

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

安定性と保存 Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
別名CAS: 3028439-63-3
背景

Programmed cell death 1 ligand 1 is a ~33 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis.

1. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443
2. Mezzadra, R. et al. (2017) Nature 549, 106-110. PMID: 28813410
3. Burr, ML. et al. (2017) Nature 549, 101-105. PMID: 28813417
4. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419
5. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298
6. Dong, H. et al. (1999) Nature medicine 5, 1365-9. PMID: 10581077
7. Hou, J. et al. (2020) Nature cell biology 22, 1264-1275. PMID: 32929201
注意事項 For research use only.
イメージ
  • Research Grade fetrastobart

    SDS-PAGE

    SDS-PAGE for Research Grade fetrastobart

参考文献
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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