Recombinant Human CD340/ERBB2 Protein, C-His (HY286011)

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Спецификация:

50ug
100ug
1mg

Количество:

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Даташит

Обзор

Каталожный номер	HY286011
Описание	Recombinant Human CD340/ERBB2 Protein, C-His (HY286011) expressed in Mammalian Cells, spanning Met1-Thr652. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	Mammalian Cells
Номер доступа	P04626
Длина белка	Met1-Thr652
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	72.84 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein
Фон	Receptor tyrosine-protein kinase erbB-2 (CD340/ERBB2) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. CD340 is the therapeutic target of trastuzumab (Herceptin) and trastuzumab deruxtecan (Enhertu).
Примечание	For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Recombinant Human CD340/ERBB2 Protein, C-His
Bioactivity

Detects Ertumaxomab in indirect ELISAs.
Bioactivity

Detects M802 in indirect ELISAs.
Bioactivity

Detects Margetuximab in indirect ELISAs.
Bioactivity

Detects Zanidatamab in indirect ELISAs.
Bioactivity

Detects Zenocutuzumab in indirect ELISAs.
Bioactivity

Detects Runimotamab in indirect ELISAs.
Western blot

Detected by Anti-CD340/ERBB2 monoclonal antibody (Catalog No: HW664107)
Bioactivity

Detected by Cinrebafusp alfa (Catalog No: HC336186) in indirect ELISA.
Bioactivity

Detected by MEDI4276 (Catalog No: HY286566) in indirect ELISA.
Bioactivity

Detected by Anbenitamab (Catalog No: HY286106) in indirect ELISA.
Bioactivity

Detected by Anvatabart (Catalog No: HY286156) in indirect ELISA.
Bioactivity

Detected by Calotatug (Catalog No: HY286746) in indirect ELISA.
Bioactivity

Detected by Iv0231 (Catalog No: HY286030) in indirect ELISA.

Ссылки

HY286011-SDS-PAGE-1.jpg

Даташит

Recombinant Human CD340/ERBB2 Protein, C-His.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа