Immune Checkpoint Proteins

Q: Receptor vs. ligand—how should I choose?

Use receptors for capture/immobilization or signaling models; use ligands for blocking/competition or bidirectional pairing. Many workflows test both orientations.

Q: Why use Fc-fusion checkpoints?

Fc improves stability/avidity and simplifies capture. Ensure Fc does not interfere with readouts in functional assays.

Q: Recommended endotoxin for immune assays?

Commonly ≤0.1 EU/µg. Verify the lot-specific CoA and include suitable assay controls.

Q: RUO disclaimer

All products are for Research Use Only and not for diagnostic procedures.

Home > Products > Recombinant Proteins > Immune Checkpoint Proteins

Explore bioactive recombinant immune-checkpoint ligands and receptors for T-cell activation, exhaustion, and myeloid-cell regulation studies. Expressed in HEK293/CHO to preserve native PTMs, our portfolio includes Fc-chimeras and His-tag carrier-free formats for binding assays (ELISA/SPR/BLI), cell-based reporters, and blocking/activation workflows. Each lot is verified for purity (typical ≥95%), endotoxin (typical ≤0.1 EU/µg) and activity with lot-specific CoAs. RUO

Why Researchers Choose abinScience

Activity-Validated Ligands/receptors; lot-to-lot consistency with CoA

Mammalian Expression HEK293/CHO for native folding/glycosylation

Flexible Formats Fc-fusion (stability/avidity), His-tag, carrier-free

Low Endotoxin Options for sensitive immune-cell assays

Scalable & Global Sizes; cold-chain shipping

Popular Subcategories

Selection Guide

Application: Blocking/activation vs. binding; choose Fc-fusion for avidity and plate capture, His-tag for purification and SPR/BLI coupling.
Species & Pairing: Match species (human/mouse) and use biologically relevant ligand–receptor pairs.
Expression System: Prefer HEK293/CHO for glycosylated checkpoints; E. coli for rapid screens.
Endotoxin: Target ≤0.1 EU/µg for primary immune-cell assays; confirm lot-specific CoA.

Applications

T-cell activation/exhaustion modeling; co-stimulation and co-inhibition studies

Binding kinetics & affinity (ELISA/SPR/BLI)

Antibody discovery: blocking/neutralization and mechanism-of-action assays

Cell-based reporter assays and immune-synapse reconstruction

Documents & QC

CoA with purity, endotoxin and activity method

SDS-PAGE/HPLC images; reconstitution & storage instructions

FAQs

Receptor vs. ligand—how should I choose?

Use the receptor for capture/immobilization or signaling models; use the ligand for blocking/competition or bidirectional pairing. Many assays benefit from testing both orientations.

Why use Fc-fusion checkpoints?

Fc domains improve stability and avidity, simplify capture/purification, and support plate-based and cell-based formats; ensure Fc does not confound your readout.

Recommended endotoxin for immune assays?

Typically ≤0.1 EU/µg. Always verify the lot-specific CoA and include appropriate controls.

RUO disclaimer

All products are for Research Use Only and not for diagnostic procedures.

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