Please ensure Javascript is enabled for purposes of website accessibility
Contact us Contact Us
EN
Home > Research Area > Neuroscience > Bipolar Disorder

Bipolar Disorder Research Reagents

Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes of mania and depression, affecting approximately 2% of the global population. Pathophysiology involves GSK3β signaling dysregulation (lithium’s primary target), mitochondrial dysfunction, neuroinflammation, and circadian rhythm disruption. Biomarker research focuses on peripheral inflammatory markers and BDNF levels as state-dependent indicators.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

Bipolar Disorder Research Reagents - key pathogenic pathways and research targets

Fig. 1 Key pathogenic pathways and research targets. abinScience product targets highlighted in orange.

abinScience provides validated antibodies, recombinant proteins, and ELISA kits for key bipolar disorder research targets. All products are manufactured by our parent company AtaGenix Laboratories under ISO quality systems. Browse products below or contact us for custom antibody development.

Key Research Targets

GSK3β — GSK3β is the principal therapeutic target of lithium in bipolar disorder, regulating glycogen metabolism, Wnt signaling, and circadian rhythms. Anti-GSK3β and anti-phospho-GSK3β antibodies enable lithium mechanism-of-action studies and mood stabilizer research.
→ Browse GSK3β antibodies & proteins

BDNF — Peripheral BDNF levels are reduced during depressive episodes and elevated during mania, serving as a potential state biomarker. Anti-BDNF antibodies support ELISA-based longitudinal monitoring and neuroplasticity research in BD.
→ Browse BDNF antibodies & proteins

Inflammatory Cytokines (IL-6, TNF-α) — Elevated pro-inflammatory cytokines are consistently observed in bipolar disorder across mood states. Anti-IL-6 and anti-TNF-α antibodies and ELISA kits support neuroinflammation profiling and treatment response monitoring.
→ Browse cytokine antibodies & ELISA kits

References

1. Grande I, et al. Bipolar disorder. Lancet. 2016;387(10027):1561-1572. DOI

2. Jope RS. Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci. 2003;24(9):441-443. DOI

3. Munkholm K, et al. Cytokines in bipolar disorder: a systematic review and meta-analysis. J Affect Disord. 2013;144(1-2):16-27. DOI

4. Fernandes BS, et al. Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders. Acta Psychiatr Scand. 2011;123(5):350-358. DOI

8 product results for "Bipolar Disorder"

Options+
Options
Confirm

Quick access

Contact Us

  • +86-27-87433958

  • info@abinscience.com

  • Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China

  • linkedin
  • Ins
  • youtube
  • youtube
Copyright © 2026 abinScience. All Rights Reserved. All Products are for Research Use Only