Human Respiratory Syncytial Virus (HRSV) Reag

Research-grade reagents for Human Respiratory Syncytial Virus (HRSV) — a leading cause of lower respiratory tract infection in infants, elderly, and immunocompromised populations. F protein (pre-fusion/post-fusion conformations) and G protein are primary vaccine and therapeutic antibody targets. We offer recombinant/polyclonal/InVivoMAb antibodies, recombinant proteins, assay kits, validated for ELISA, Western blot, immunohistochemistry, flow cytometry, immunofluorescence, neutralization, surface plasmon resonance (SPR), and blocking assays. Comprehensive coverage of F/G proteins and non-structural antigens supports vaccine design, monoclonal antibody therapeutics development, diagnostic assay optimization, and mechanistic studies of fusion inhibition and immune escape mechanisms critical for RSV drug discovery. RUO

Why Researchers Choose abinScience

Recombinant Antibodies (37) Epitope-mapped clones targeting conserved and variable regions of F and G proteins. Suitable for ELISA, Western blot, immunoassay development, and as reference standards for diagnostic R&D and assay validation.

Polyclonal Antibodies (14) Broad epitope recognition for Western blot and immunohistochemistry detection. Validated for ELISA, WB, IHC, FCM, IF, neutralization assays, surface plasmon resonance (SPR), and blocking studies with high specificity across HRSV strains.

InVivoMAb Functional-Grade (16) Low-endotoxin, azide-free antibodies for in vivo neutralization, passive immunization, and functional blocking studies. Includes fusion-inhibitory clones and pre-fusion F protein-specific antibodies with validated protective activity in animal models.

Recombinant Proteins (25) His-tagged and Fc-tagged HRSV antigens (F, G, N, M, M2, L, and fusion variants) validated for SDS-PAGE, Western blot, and ELISA. Suitable as immunogens for monoclonal antibody generation, coating antigens for high-throughput screening, and assay standards for vaccine potency testing.

Assay Kits (4) Ready-to-use ELISA kits for quantitative HRSV antigen or antibody detection with lot-specific validation data, optimal antibody pair ratios, and positive/negative control materials for diagnostic and research applications.

All products manufactured by AtaGenix Laboratories under ISO 9001 & ISO 13485 quality systems.

References

1. Melero JA, García-Barreno B, Martínez I, et al. Structural and functional analysis of F protein mutants of respiratory syncytial virus. Virology. 1997;239(2):298-306. DOI

2. Joyce MG, Wheatley AK, Thomas PV, et al. Immunization-induced respiratory syncytial virus (RSV)-specific dynamic lung memory B-cell response and protection by natural killer cells. Proc Natl Acad Sci USA. 2020;117(43):26675-26682. DOI

3. Openshaw PJ, Chiu C, Wertz GW, Askonas BA. Respiratory syncytial virus--specific cytotoxic T cells provided heterosubtypic immunity to A2 influenza in mice. J Virol. 1997;71(1):177-183. DOI

4. Empey KM, Peebles RS, Egerman FM, et al. Infection with respiratory syncytial virus primes mice for enhanced allergic airway responses to house dust mite. Clin Exp Allergy. 2007;37(9):1348-1357. DOI