CD3E/CD3ε/CD3 epsilon

The T-cell antigen receptor (TCR) consists of multiple subunits, including the alpha chain (see 186880), beta chain (see 186930), gamma chain (see 186740), delta chain (see 186790), epsilon chain, and zeta chain (see 186780). The gamma, delta, epsilon, and zeta chains together form the T3 complex, while the alpha and beta chains are linked by disulfide bonds. Among these, the gamma and delta T3 membrane proteins are glycoproteins, whereas T3-epsilon is not glycosylated. In 1986, Gold et al. successfully cloned the cDNA sequence of the T3-epsilon gene (T3E), providing crucial insights into T-cell receptor signal transduction.