Multiple Sclerosis Reagents

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abinScience provides high-quality recombinant proteins, validated monoclonal antibodies, and RUO ELISA kits specifically for multiple sclerosis research, focusing on key therapeutic targets (CD20, ITGA4, S1PR1, BTK), leukocyte markers, neurotrophic factors (BDNF), and remyelination-related proteins (LINGO1). Every lot is released with detailed CoA documenting purity, endotoxin, linearity, spike-recovery and precision. For research use only (RUO).

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Selection guide

Therapeutic target: Select surface antigens (CD20, ITGA4, S1PR1, CD52) for immune cell depletion/trafficking studies; intracellular kinases (BTK, TYK2) for signaling research.
Neuroprotection & repair: BDNF and LINGO1 reagents for neurotrophic and remyelination mechanism studies.
Sample matrix: CSF, serum/plasma, PBMCs, and brain tissue — follow CoA-recommended dilution and matrix effects.
Assay setup: Use 4PL/5PL curve fitting for ELISA; include calibrators and QC samples.
Specificity: Verify phospho-specificity for signaling proteins and cross-reactivity for leukocyte markers.

Spotlight

Integrin α4 Recombinant

Purity ≥98% • Native pairing • Ideal for adhesion assays

Anti-CD20 (mAb) — Depleting/WB/FC

High affinity • Low endotoxin • Clinical-grade mimic

BDNF ELISA Kit (RUO)

Validated LoD/LoQ • CSF & serum protocols • High precision

FAQs

Why are B-cell targets prominent in MS research?

B-cell depletion with anti-CD20 therapies (e.g., ocrelizumab) is highly effective; reagents targeting CD20, CD19, and BTK enable studies of B-cell roles in antigen presentation and autoantibody-independent pathology.

Role of trafficking and sphingosine modulators?

ITGA4 blockade prevents lymphocyte entry into CNS; S1PR1 modulation traps lymphocytes in lymph nodes. Corresponding recombinant proteins and antibodies support mechanistic research.

Are these products cleared for diagnostic use?

All products are for Research Use Only (RUO) and are not intended for use in diagnostic procedures.