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Zebrafish (Danio rerio) Research Reagents

Browse Zebrafish (Danio rerio) antibodies and recombinant proteins — species-validated reagents for developmental biology, disease modeling, and comparative studies. The zebrafish genome shares approximately 70% orthology with the human genome, and its transparent embryos, external fertilization, rapid generation time (~3 months), and genetic tractability via CRISPR/Cas9, morpholinos, and forward genetic screens have established Danio rerio as one of the most widely used vertebrate model organisms. Our reagents support research across organogenesis and embryonic axis formation, regenerative biology (heart, fin, retina, spinal cord), human disease modeling (cancer xenografts, cardiovascular, neurological, metabolic disorders), toxicology and drug screening, and immunology (innate immune development, neutrophil/macrophage biology). RUO

Species-Specific Validation Antibodies validated with confirmed reactivity to zebrafish targets using species-appropriate positive controls and lysates from zebrafish embryos and adult tissues.
Broad Target Coverage Immune markers, signaling molecules (Wnt, Notch, BMP, FGF), structural proteins, transcription factors, and disease-relevant biomarkers across developmental stages.
Cross-Reactivity Data Detailed species cross-reactivity information provided on every product datasheet, enabling comparative studies across teleost and mammalian model systems.
Multiple Applications Validated for WB, IHC (whole-mount and section), IF, ELISA, and FC across developmental, regenerative, and comparative biology research workflows.
Original Manufacturer In-house production under ISO 9001 & ISO 13485 quality systems — reliable supply, consistent lot-to-lot performance, and lot-specific CoA and validation data on every product page.

FAQs

How are your antibodies validated?

Every antibody is validated in its listed applications (WB, IHC, IF, ELISA, FC) with supporting images and data on the product page. We use positive and negative controls plus knockout/knockdown verification where available.

Do you offer conjugated antibodies?

Yes — HRP, AP, biotin, FITC, PE, APC, Alexa Fluor, and other fluorochrome conjugates are available. Custom conjugation services are also offered for bulk orders.

What species do your antibodies react with?

Most antibodies target human, mouse, and rat. Many show validated cross-reactivity with additional species including zebrafish. Check the product datasheet for confirmed reactivity data.

What is your replacement policy?

If a product does not perform as described under recommended conditions, contact us within 30 days for replacement or credit. Our technical team will help troubleshoot first.

Can I get custom antibodies?

Yes — our parent company AtaGenix offers full custom antibody development from immunogen design through hybridoma screening and scale-up production.

All products manufactured by AtaGenix Laboratories under ISO 9001 & ISO 13485 quality systems.

References

1. Howe K, Clark MD, Torroja CF, et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013;496(7446):498-503. DOI

2. Lieschke GJ, Currie PD. Animal models of human disease: zebrafish swim into view. Nat Rev Genet. 2007;8(5):353-367. DOI

3. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. Stages of embryonic development of the zebrafish. Dev Dyn. 1995;203(3):253-310. DOI

4. Holtzman NG, Iovine MK, Liang JO, Morris J. Learning to fish with genetics: a primer on the vertebrate model Danio rerio. Genetics. 2016;203(3):1069-1089. DOI

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