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PK Assay Kits

abinScience PK assay kits quantify therapeutic proteins & antibodies in serum/plasma using anti-idiotype, antigen-capture, and generic IgG formats across ELISA and ECL platforms. Full validation: LLOQ/ULOQ, accuracy, precision, selectivity, dilution linearity. RUO

Why Researchers Choose abinScience

Multiple Formats Anti-idiotype, antigen-capture, generic IgG
Dual Platforms ELISA & high-range ECL (MSD-style)
Free vs Total With optional acid dissociation
Lot-Specific QC LLOQ/ULOQ, accuracy, precision, selectivity
Matrix Validated Serum/plasma protocols, MRD guidance

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Selection & Assay Guide

  1. Drug Modality: Use anti-idiotype for mAbs; generic IgG for high-throughput or ligand interference; antigen-capture for target-binding studies.
  2. Free vs Total: Measure total drug with acid dissociation if target/ADA complexes present; use non-dissociated for free drug.
  3. Platform: ELISA for routine; ECL for wide dynamic range and low background.
  4. Performance: Verify LLOQ/ULOQ, recovery, CV; check selectivity, dilution linearity, avoid hook effect.
  5. Interference: Follow ADA and target protein tolerance; set MRD; use F(ab’)₂ probes if needed.

Applications

Serum/plasma PK profiling of mAbs and Fc-fusion proteins
Bioanalytical method development and tech transfer (RUO)
Bridging to ADA/NAb workflows with matched reagents

FAQs

When to choose anti-idiotype vs antigen-capture?

Anti-idiotype offers highest drug specificity for mAbs; antigen-capture is useful when anti-Id is unavailable or to assess target-bound (active) drug states.

What’s the difference between free and total drug?

Free drug quantifies unbound drug; total drug includes bound (to target/ADA) and unbound after acid dissociation per protocol.

ELISA or ECL?

ELISA is cost-effective and widely accessible; ECL provides wider dynamic range and lower background for high-concentration samples.

How to evaluate LLOQ/ULOQ suitability?

Ensure calibration curve covers expected Cmin–Cmax. Lot-specific LLOQ/ULOQ must meet accuracy (80–120%) and precision (CV ≤15–20%) criteria.

RUO disclaimer

All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

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