Tree Shrew (Tupaia) Research Reagents

Browse Tree Shrew (Tupaia belangeri chinensis) antibodies and recombinant proteins — species-validated reagents for infectious disease modeling, neuroscience, and comparative primate biology. The Chinese tree shrew (order Scandentia) is a squirrel-sized mammal whose phylogenomic analysis places it as the closest living non-primate relative to primates, with a high brain-to-body mass ratio, short reproductive cycle (~6 weeks gestation), small body size (~150 g), and low maintenance cost. Genome sequencing has revealed conserved nervous and immune system signaling pathways shared with primates, providing a cost-effective alternative to primate models where ethical and logistical constraints limit non-human primate use. Tree shrews are uniquely susceptible to clinically important human pathogens, supporting naturally occurring disease models for hepatitis B and C virus infection (one of the few non-primate species supporting HBV/HCV entry and replication), herpes simplex virus type 1 (HSV-1), myopia (form-deprivation and lens-induced models with human-like scleral remodeling), depression and psychosocial stress (chronic subordination paradigm with translatable cortisol-based endpoints), breast cancer, and alcohol-induced and non-alcoholic fatty liver disease. Our reagents support immunophenotyping, tissue imaging, and functional studies across these disease models and comparative neurobiology research. RUO

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