Anti-KCNAB2 Polyclonal Antibody (HA563014)

Name: Anti-KCNAB2 Polyclonal Antibody
Brand: abinScience
SKU: HA563014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HA563014

Description

Anti-KCNAB2 Polyclonal Antibody (HA563014) is a rabbit polyclonal antibody detecting KCNAB2 in WB, IHC, ELISA. Suitable for Human, Mouse, Rat, Dog, and Cat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

WB,IHC,ELISA

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human KCNAB2 (Gln37-Ser367).

Target

Voltage-gated potassium channel subunit beta-2, EC:1.1.1.-, K(+) channel subunit beta-2, Kv-beta-2, hKvbeta2, KCNAB2

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Accession

Q13303

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

Voltage-gated potassium channel subunit beta-2, EC:1.1.1.-, K(+) channel subunit beta-2, Kv-beta-2, hKvbeta2, KCNAB2

Background

Voltage-gated potassium channel subunit beta-2 (KCNAB2) is a ~41 kDa protein. Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels. Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates. Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet).

1. McCormack, K. et al. (2002) The Journal of biological chemistry 277, 13219-28. PMID: 11825900

2. McCormack, K. et al. (1995) FEBS letters 370, 32-6. PMID: 7649300

Note

For research use only.

Images

References

Datasheet

Anti-KCNAB2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-KCNAB2 Polyclonal Antibody (HA563014)

Overview

Images

References

Datasheet

SDS

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