Cardiovascular Research

Cardiovascular Research Reagents

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. Research spans acute coronary syndromes, heart failure, thrombotic disorders, vascular remodeling, and atherosclerosis. Advances in circulating biomarkers (high-sensitivity troponin, NT-proBNP, sST2), lipid-lowering biologics (PCSK9 inhibitors), and anti-thrombotic therapies continue to reshape both diagnostic and therapeutic landscapes, driving demand for well-characterized research reagents across these fields.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

abinScience provides validated antibodies, recombinant proteins, and ELISA kits for key cardiovascular research targets — cardiac injury markers, coagulation cascade components, vascular regulators, and lipid metabolism mediators. All products are manufactured by our parent company AtaGenix Laboratories under ISO quality systems. Browse products below or contact us for custom development.

Cardiac Biomarkers

Troponin (cTnI / cTnT) — Cardiac troponins are the gold-standard biomarkers for myocardial injury and acute coronary syndrome diagnosis. High-sensitivity troponin immunoassays require well-characterized capture/detection antibody pairs and calibrator-grade recombinant proteins.
→ Browse Troponin antibodies & proteins

BNP / NT-proBNP — B-type natriuretic peptides are established biomarkers for heart failure diagnosis, severity stratification, and treatment monitoring. Recombinant BNP and NT-proBNP proteins support immunoassay calibration and antibody pair screening.
→ Browse BNP antibodies & proteins

sST2 (IL-33 Receptor) — Soluble ST2 is a prognostic biomarker for heart failure and myocardial fibrosis, independent of and complementary to natriuretic peptides. Anti-ST2 antibodies enable sandwich immunoassay development for cardiac risk stratification.
→ Browse sST2 antibodies & proteins

Galectin-3 — Emerging biomarker for cardiac fibrosis and adverse remodeling in heart failure. Elevated Galectin-3 predicts hospitalization risk and mortality in chronic heart failure patients.
→ Browse Galectin-3 antibodies & proteins

Coagulation & Thrombosis

Tissue Factor (CD142 / F3) — The primary initiator of the extrinsic coagulation cascade. Tissue Factor expression on tumor cells and activated endothelium links thrombosis to cancer and inflammation. Recombinant TF proteins support coagulation assay development and anti-TF antibody screening.
→ Browse Tissue Factor antibodies & proteins

von Willebrand Factor (vWF) — Multimeric glycoprotein essential for platelet adhesion and Factor VIII stabilization. vWF deficiency causes von Willebrand disease, the most common inherited bleeding disorder. Anti-vWF antibodies support multimer analysis, ELISA quantification, and functional platelet adhesion studies.
→ Browse vWF antibodies & proteins

Fibrinogen — Central substrate of the coagulation cascade, cleaved by thrombin to form fibrin clots. Fibrinogen is also an acute-phase reactant and cardiovascular risk marker.
→ Browse Fibrinogen antibodies & proteins

PAI-1 (SERPINE1) — Primary inhibitor of tissue plasminogen activator (tPA) and urokinase. Elevated PAI-1 is associated with thrombotic risk and metabolic syndrome. A key target in fibrinolysis research.
→ Browse PAI-1 antibodies & proteins

Vascular Biology

VEGF Family — Vascular endothelial growth factors are master regulators of angiogenesis and vascular permeability. VEGF-A/VEGFR2 signaling is the primary target of anti-angiogenic cancer therapies (bevacizumab, ramucirumab) and is central to ischemic heart disease and retinal vascular research.
→ Browse VEGF antibodies & proteins

Angiopoietin / Tie2 — The Angiopoietin-Tie2 axis regulates vascular stability, inflammation, and endothelial barrier function. Ang1 promotes vascular quiescence; Ang2 sensitizes endothelium to VEGF-driven sprouting and is a biomarker for sepsis-associated vascular leak.
→ Browse Angiopoietin & Tie2 antibodies & proteins

Selectins & Adhesion Molecules (ICAM-1, VCAM-1, E-/P-Selectin) — Endothelial adhesion molecules mediate leukocyte rolling, adhesion, and transmigration during inflammation. Soluble ICAM-1 and VCAM-1 are circulating biomarkers for endothelial activation in atherosclerosis and vasculitis research.
→ Browse adhesion molecule antibodies & proteins

Lipid Metabolism & Atherosclerosis

PCSK9 — Proprotein convertase that promotes LDL receptor degradation, raising circulating LDL cholesterol. PCSK9 inhibitors (evolocumab, alirocumab) represent a major class of lipid-lowering biologics. Recombinant PCSK9 proteins support drug screening, binding assays, and ADA reagent generation.
→ Browse PCSK9 antibodies & proteins

Apolipoproteins (ApoA, ApoB, ApoE) — Structural and functional components of lipoprotein particles. ApoB-100 is the primary protein of LDL and a direct measure of atherogenic particle number. ApoE isoforms (E2/E3/E4) modulate Alzheimer’s risk and lipid clearance.
→ Browse Apolipoprotein antibodies & proteins

LOX-1 (OLR1) — The primary endothelial receptor for oxidized LDL. LOX-1 activation promotes endothelial dysfunction, foam cell formation, and plaque instability. An emerging therapeutic target and circulating biomarker for acute coronary events.
→ Browse LOX-1 antibodies & proteins

References

1. Thygesen K, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;40(3):237-269. DOI

2. McDonagh TA, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-3726. DOI

3. Sabatine MS, et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. N Engl J Med. 2017;376(18):1713-1722. DOI

4. Libby P. The changing landscape of atherosclerosis. Nature. 2021;592(7855):524-533. DOI