Browse recombinant proteins and antibodies for major cell signaling cascades — from receptor-level ligands to downstream transcription factors across Notch, WNT, TGF-β/SMAD, MAPK/ERK, and PI3K/AKT/mTOR pathways. These pathways regulate fundamental processes including cell proliferation, differentiation, survival, and apoptosis, and their dysregulation is implicated in cancer, developmental disorders, fibrosis, and inflammatory disease. Our signaling reagents support pathway dissection, drug target validation, biomarker screening, and functional assays. All products are manufactured in-house with lot-specific QC data and designated Research Use Only (RUO). RUO
Browse by Pathway
Why Researchers Choose abinScience
Five Core Pathways, One Source Reagents covering Notch, WNT, TGF-β/SMAD, MAPK/ERK, and PI3K/AKT/mTOR — from ligands and receptors to kinases and transcription factors. Over 300 products across these cascades.
Full Cascade Coverage Not just the headline targets — we stock upstream ligands, membrane receptors, intracellular kinases, adaptor proteins, and nuclear effectors within each pathway, enabling systematic pathway interrogation.
Multi-Format Availability Key targets such as Notch1, DLL4, TGF-β1, and AKT are available as recombinant proteins (His-tag, Fc-tag, Avi-tag), polyclonal antibodies, and recombinant monoclonal antibodies — supporting diverse experimental workflows from ELISA to functional assays.
Cross-Pathway & Cross-Disease Utility Signaling pathways intersect extensively. Our catalog enables researchers working in oncology, immunology, neuroscience, or developmental biology to source pathway reagents without switching suppliers.
Manufacturer-Direct Pricing All signaling pathway reagents are developed and produced at our Wuhan facility. No distributor markup — competitive pricing with full traceability from gene to final product.
How to Select the Right Product
1 Pathway & Target Node: Identify where in the signaling cascade your experiment needs coverage — e.g., the Notch1 receptor for cleavage studies, β-Catenin for nuclear translocation assays, or AKT for phosphorylation-dependent readouts. Use the pathway sub-pages below to browse by cascade.
2 Product Format: Choose recombinant proteins for functional assays, ligand-receptor binding studies, and immunization; antibodies for Western blot, IHC, IF, and flow cytometry detection of pathway activation markers.
3 Tag & Species Considerations: For SPR or BLI binding assays, select Fc-tagged proteins for oriented capture. For structural studies, choose His-tagged proteins for minimal steric interference. Multi-species reactivity (Human, Mouse) is listed on each product page.
Documents & QC Data
Download CoA, SDS-PAGE, SEC-HPLC, and binding ELISA data on each product page. Sequence information, expression system, and endotoxin levels are included where applicable.
FAQs
Which signaling pathways does abinScience currently cover?
We offer reagents for five major cascades: Notch (Notch1/2/3, DLL1/4, Jagged1), WNT (WNT3A, WNT5A, β-Catenin, Frizzled receptors, Axin, GSK-3β), TGF-β/SMAD (TGF-β1, TGFβR1/R2, SMAD2/3/4/7), MAPK/ERK (RAS, RAF, MEK, ERK1/2, JNK, p38), and PI3K/AKT/mTOR (PI3K, AKT1/2/3, mTOR, S6K, PTEN). Each pathway sub-page lists all available targets and products.
Can I use the recombinant ligands (DLL4, WNT3A, TGF-β1) in cell-based functional assays?
Yes. Many of our recombinant ligands are produced in mammalian expression systems (HEK293) to ensure proper folding and post-translational modifications. Check each product page for bioactivity data and recommended working concentrations. For plate-coating applications (e.g., immobilized DLL4 for Notch activation), Fc-tagged formats are recommended.
What is the difference between His-tagged and Fc-tagged proteins?
His-tag (6×His): Minimal tag (∼1 kDa) ideal for ELISA coating, structural studies, and applications where tag interference must be minimized. Fc-tag (human IgG1 Fc): Larger fusion (∼25 kDa) that enables Protein A/G capture for oriented immobilization, extends serum half-life for in vivo use, and provides natural dimerization for receptor-ligand binding assays (e.g., SPR, BLI).
A signaling target I need is not listed. Can you develop it?
Yes. Our parent brand AtaGenix offers custom recombinant protein expression and antibody development services. We can produce signaling pathway proteins with custom tags, species variants, or mutant forms. Contact us with your target and specifications for a project assessment.
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