Autism Spectrum Disorder Research Reagents

SHANK3 — SHANK3 is a postsynaptic scaffolding protein essential for glutamatergic synapse organization. SHANK3 haploinsufficiency causes Phelan-McDermid syndrome with high ASD penetrance. Anti-SHANK3 antibodies support synaptic density quantification and gene therapy research.
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mTOR Pathway (mTOR, TSC1/TSC2) — mTOR hyperactivation (via TSC1/2 loss) drives ASD in tuberous sclerosis complex. Anti-mTOR and anti-phospho-S6K antibodies enable PI3K/Akt/mTOR signaling studies and rapamycin treatment mechanism research.
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Oxytocin / Oxytocin Receptor — Oxytocin modulates social behavior and is under clinical investigation for ASD social deficits. Anti-oxytocin receptor antibodies and recombinant oxytocin support receptor expression profiling and social neuroscience research.
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2. Bourgeron T. From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci. 2015;16(9):551-563. DOI

3. Sato A. mTOR, a potential target to treat autism spectrum disorder. CNS Neurol Disord Drug Targets. 2016;15(5):533-543. DOI

4. Parker KJ, et al. Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. Proc Natl Acad Sci USA. 2014;111(33):12258-12263. DOI