abinScience offers high-specificity monoclonal and polyclonal antibodies targeting PEG backbone (anti-PEG) and methoxy terminus (anti-mPEG) for ADA (anti-drug antibody) screening, confirmatory, titer, and PK ELISA applications. Conjugation options include HRP, Biotin, and fluorescent labels (AF488/AF647). Each lot includes a Certificate of Analysis (CoA) with purity, endotoxin, and performance data. RUO
What is the difference between anti-PEG and anti-mPEG?
anti-PEG recognizes the repeating backbone unit (—CH₂CH₂O—) and offers broad applicability across PEG sizes. anti-mPEG preferentially binds the methoxy terminal group and is optimized for use with mPEG-BSA coated plates or terminal-specific analysis.
How to choose between IgG and IgM?
IgM delivers high-avidity, multivalent binding—ideal for capture antibodies in screening or PK assays. IgG is better suited for detection, confirmatory steps, and competitive inhibition assays. Selection depends on assay readout (A₄₅₀, titer, % inhibition) and background signal.
Are there matrix or surfactant interferences?
Formulations containing polysorbate (Tween) or other surfactants may interfere with binding or increase background. Always follow the CoA-recommended MRD, validate spiked recovery, and include blank matrix controls.
RUO disclaimer
All products are for Research Use Only (RUO) and are not intended for diagnostic or therapeutic procedures.
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