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Fibromyalgia / Chronic Widespread Pain Research Reagents

Fibromyalgia is a chronic widespread pain disorder affecting 2–4% of the population, characterized by central sensitization, altered pain processing, and associated symptoms including fatigue, sleep disturbance, and cognitive dysfunction. Pathophysiology involves elevated CSF substance P, reduced descending serotonergic/noradrenergic inhibition, small fiber neuropathy, and neuroinflammation. Biomarker development remains a critical unmet need for diagnosis and treatment stratification.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

Fibromyalgia / Chronic Widespread Pain Research Reagents - key pathogenic pathways and research targets

Fig. 1 Key pathogenic pathways and research targets. abinScience product targets highlighted in orange.

abinScience provides validated antibodies, recombinant proteins, and ELISA kits for key fibromyalgia and chronic pain research targets. All products are manufactured by our parent company AtaGenix Laboratories under ISO quality systems. Browse products below or contact us for custom antibody development.

Key Research Targets

Substance P (TAC1) — CSF substance P levels are consistently elevated in fibromyalgia, reflecting augmented nociceptive signaling. Anti-substance P antibodies and recombinant proteins support central sensitization research and pain biomarker assay development.
→ Browse Substance P antibodies & proteins

NGF (Nerve Growth Factor) — NGF drives peripheral nociceptor sensitization and small fiber pathology in fibromyalgia. Anti-NGF antibodies (tanezumab, fasinumab class) and recombinant NGF proteins support pain mechanism studies.
→ Browse NGF antibodies & proteins

IL-6 / TNF-α — Elevated serum IL-6 and TNF-α are reported in fibromyalgia, linking systemic inflammation to central sensitization. Cytokine antibodies and ELISA kits support inflammatory profiling and treatment response monitoring.
→ Browse cytokine antibodies & ELISA kits

References

1. Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547-1555. DOI

2. Russell IJ, et al. Elevated cerebrospinal fluid levels of substance P in patients with fibromyalgia syndrome. Arthritis Rheum. 1994;37(11):1593-1601. DOI

3. Üçeyler N, et al. Small fibre pathology in patients with fibromyalgia syndrome. Brain. 2013;136(6):1857-1867. DOI

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