Anti-Human CLOCK Polyclonal Antibody (HT219014)

Name: Anti-Human CLOCK Polyclonal Antibody
Brand: abinScience
SKU: HT219014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT219014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CLOCK (Ser106-Gly390).

Target

hCLOCK, bHLHe8, Class E basic helix-loop-helix protein 8, BHLHE8, Circadian locomoter output cycles protein kaput, CLOCK, KIAA0334

Purification

Purified by antigen affinity column.

Accession

O15516

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Circadian locomoter output cycles protein kaput (CLOCK) is a ~95 kDa protein. Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers').

1. Wang, Z. et al. (2013) Cell research 23, 213-24. PMID: 23229515

2. Charmandari, E. et al. (2011) PloS one 6, e25612. PMID: 21980503

3. Lin, R. et al. (2017) Molecular cell 68, 198-209.e6. PMID: 28985504

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human CLOCK polyclonal antibody at 1ug/mL on recombinant Human CLOCK (Catalog No. HT219012).

References

Datasheet

Anti-Human CLOCK Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CLOCK Polyclonal Antibody (HT219014)

Overview

Images

References

Datasheet

SDS

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