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| カタログ番号 | MB263012 |
|---|---|
| 説明 |
Recombinant Mouse SPN Protein, N-His-KSI (MB263012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P15702 |
| タンパク質長 | Asp20-Gly248 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | B-cell differentiation antigen LP-3, CD43, CD43 cytoplasmic tail, CD43-ct, CD43ct, Leukocyte sialoglycoprotein, Leukosialin, Ly-48, Lymphocyte antigen 48, Sialophorin, Spn |
| 背景 | Leukosialin is a ~40 kDa protein. Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. 1. Allenspach, EJ. et al. (2001) Immunity 15, 739-50. PMID: 11728336 2. Mody, PD. et al. (2007) Blood 110, 2974-82. PMID: 17638845 3. Cannon, JL. et al. (2011) Molecular biology of the cell 22, 954-63. PMID: 21289089 4. Cannon, JL. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 7385-93. PMID: 18490738 5. Velázquez, F. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 1305-1316. PMID: 26700769 6. van den Berg, TK. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 3637-40. PMID: 11238599 |
| 注意事項 | For research use only |
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