

| Numéro de catalogue | MF658012 |
|---|---|
| Description |
Recombinant Mouse AIFM1 Protein, N-His (MF658012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | Q9Z0X1 |
| Longueur de protéine | Val131-Lys321 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Mus musculus (Mouse) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | Aif, Aifm1, Apoptosis-inducing factor 1, mitochondrial, EC:1.6.99.-, Pdcd8, Programmed cell death protein 8 |
| Contexte | Apoptosis-inducing factor 1, mitochondrial is a ~66 kDa protein. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. 1. Yu, SW. et al. (2002) Science (New York, N.Y.) 297, 259-63. PMID: 12114629 2. Wang, Y. et al. (2011) Science signaling 4, ra20. PMID: 21467298 3. Susin, SA. et al. (1999) Nature 397, 441-6. PMID: 9989411 4. Sevrioukova, IF. (2009) Journal of molecular biology 390, 924-38. PMID: 19447115 |
| Note | For research use only |
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