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| カタログ番号 | MF658012 |
|---|---|
| 説明 |
Recombinant Mouse AIFM1 Protein, N-His (MF658012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9Z0X1 |
| タンパク質長 | Val131-Lys321 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Aif, Aifm1, Apoptosis-inducing factor 1, mitochondrial, EC:1.6.99.-, Pdcd8, Programmed cell death protein 8 |
| 背景 | Apoptosis-inducing factor 1, mitochondrial is a ~66 kDa protein. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. 1. Yu, SW. et al. (2002) Science (New York, N.Y.) 297, 259-63. PMID: 12114629 2. Wang, Y. et al. (2011) Science signaling 4, ra20. PMID: 21467298 3. Susin, SA. et al. (1999) Nature 397, 441-6. PMID: 9989411 4. Sevrioukova, IF. (2009) Journal of molecular biology 390, 924-38. PMID: 19447115 |
| 注意事項 | For research use only |
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