

| Каталожный номер | MF658012 |
|---|---|
| Описание |
Recombinant Mouse AIFM1 Protein, N-His (MF658012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Система экспрессии | E. coli |
| Номер доступа | Q9Z0X1 |
| Длина белка | Val131-Lys321 |
| Применения | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Виды | Mus musculus (Mouse) |
| Характер | Recombinant |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Чистота | >90% as determined by SDS-PAGE. |
| Форма | Lyophilized |
| Буфер хранения | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Реконституция | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Доставка | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | Aif, Aifm1, Apoptosis-inducing factor 1, mitochondrial, EC:1.6.99.-, Pdcd8, Programmed cell death protein 8 |
| Фон | Apoptosis-inducing factor 1, mitochondrial is a ~66 kDa protein. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. 1. Yu, SW. et al. (2002) Science (New York, N.Y.) 297, 259-63. PMID: 12114629 2. Wang, Y. et al. (2011) Science signaling 4, ra20. PMID: 21467298 3. Susin, SA. et al. (1999) Nature 397, 441-6. PMID: 9989411 4. Sevrioukova, IF. (2009) Journal of molecular biology 390, 924-38. PMID: 19447115 |
| Примечание | For research use only |
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