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| カタログ番号 | MF669012 |
|---|---|
| 説明 |
Recombinant Mouse ALDH1A1 Protein, N-His (MF669012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P24549 |
| タンパク質長 | Lys36-Gly271 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 3-deoxyglucosone dehydrogenase, ALDH-E1, ALHDII, Ahd-2, Ahd2, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, Aldh1, Aldh1a1, EC:1.2.1.19, EC:1.2.1.28, EC:1.2.1.3, EC:1.2.1.36, RALDH 1, RalDH1, Retinal dehydrogenase 1 |
| 背景 | Aldehyde dehydrogenase 1A1 is a ~54 kDa protein. Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. 1. Molotkov, A. et al. (2003) The Journal of biological chemistry 278, 36085-90. PMID: 12851412 2. Lassen, N. et al. (2007) The Journal of biological chemistry 282, 25668-76. PMID: 17567582 3. Kim, JI. et al. (2015) Science (New York, N.Y.) 350, 102-6. PMID: 26430123 |
| 注意事項 | For research use only |
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