中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | ME017012 |
|---|---|
| 説明 |
Recombinant Mouse ZBED6 Protein, N-His (ME017012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | D2EAC2 |
| タンパク質長 | Ser480-Asn779 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | MGR, Muscle growth regulator, Zbed6, Zinc finger BED domain-containing protein 6 |
| 背景 | Zinc finger BED domain-containing protein 6 is a ~109 kDa protein. Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific. Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP. Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females. Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription. Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2. 1. Markljung, E. et al. (2009) PLoS biology 7, e1000256. PMID: 20016685 2. Butter, F. et al. (2010) EMBO reports 11, 305-11. PMID: 20134481 3. Wang, X. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15997-6002. PMID: 24043816 4. Younis, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E2048-E2057. PMID: 29440408 5. Younis, S. et al. (2020) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34, 10250-10266. PMID: 32557799 6. Wang, X. et al. (2016) Scientific reports 6, 19006. PMID: 26750727 |
| 注意事項 | For research use only |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
