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| カタログ番号 | MV077012 |
|---|---|
| 説明 |
Recombinant Mouse NOD1 Protein, N-His (MV077012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q8BHB0 |
| タンパク質長 | Asp124-Gly351 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Nod1, Nucleotide-binding oligomerization domain-containing protein 1, mNod1 |
| 背景 | Nucleotide-binding oligomerization domain-containing protein 1 is a ~107 kDa protein. Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses. Specifically recognizes and binds gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), a dipeptide present in peptidoglycan of Gram-negative bacteria. Preferentially binds iE-DAP in tetrapeptide-containing muropeptides (MurNAc-TetraDAP or TetraDAP). Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2. Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling. 1. Chamaillard, M. et al. (2003) Nature immunology 4, 702-7. PMID: 12796777 2. Schertzer, JD. et al. (2011) Diabetes 60, 2206-15. PMID: 21715553 3. Magalhaes, JG. et al. (2005) EMBO reports 6, 1201-7. PMID: 16211083 4. Travassos, LH. et al. (2010) Nature immunology 11, 55-62. PMID: 19898471 5. Keestra-Gounder, AM. et al. (2016) Nature 532, 394-7. PMID: 27007849 6. Zhang, Q. et al. (2019) Cell research 29, 516-532. PMID: 31201384 |
| 注意事項 | For research use only |
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