Mouse NOD1 Recombinant Protein (N-His) (MV077012)

Name: Mouse NOD1 Recombinant Protein (N-His)
Brand: abinScience
SKU: MV077012
Price: 211 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	MV077012
Описание	Recombinant Mouse NOD1 Protein, N-His (MV077012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q8BHB0
Длина белка	Asp124-Gly351
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Mus musculus (Mouse)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	Nod1, Nucleotide-binding oligomerization domain-containing protein 1, mNod1
Фон	Nucleotide-binding oligomerization domain-containing protein 1 is a ~107 kDa protein. Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses. Specifically recognizes and binds gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), a dipeptide present in peptidoglycan of Gram-negative bacteria. Preferentially binds iE-DAP in tetrapeptide-containing muropeptides (MurNAc-TetraDAP or TetraDAP). Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2. Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling. 1. Chamaillard, M. et al. (2003) Nature immunology 4, 702-7. PMID: 12796777 2. Schertzer, JD. et al. (2011) Diabetes 60, 2206-15. PMID: 21715553 3. Magalhaes, JG. et al. (2005) EMBO reports 6, 1201-7. PMID: 16211083 4. Travassos, LH. et al. (2010) Nature immunology 11, 55-62. PMID: 19898471 5. Keestra-Gounder, AM. et al. (2016) Nature 532, 394-7. PMID: 27007849 6. Zhang, Q. et al. (2019) Cell research 29, 516-532. PMID: 31201384
Примечание	For research use only

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Mouse NOD1 Recombinant Protein (N-His).pdf

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