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| カタログ番号 | MV106022 |
|---|---|
| 説明 |
Recombinant Mouse PDPN Protein, N-His (MV106022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q62011 |
| タンパク質長 | Gly23-Leu141 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | E11, Glycoprotein 38, Gp38, OTS-8, Ots8, PA2.26 antigen, Pdpn, Podoplanin, Transmembrane glycoprotein E11 |
| 背景 | Podoplanin is a ~18 kDa protein. Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. 1. Kato, Y. et al. (2003) The Journal of biological chemistry 278, 51599-605. PMID: 14522983 2. Kaneko, M. et al. (2004) The Journal of biological chemistry 279, 38838-43. PMID: 15231832 3. Suzuki-Inoue, K. et al. (2007) The Journal of biological chemistry 282, 25993-6001. PMID: 17616532 4. Uhrin, P. et al. (2010) Blood 115, 3997-4005. PMID: 20110424 5. Astarita, JL. et al. (2015) Nature immunology 16, 75-84. PMID: 25347465 6. Scholl, FG. et al. (1999) Journal of cell science 112 ( Pt 24), 4601-13. PMID: 10574709 7. Ramirez, MI. et al. (2003) Developmental biology 256, 61-72. PMID: 12654292 8. Boucherot, A. et al. (2002) Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 17, 978-84. PMID: 12032185 |
| 注意事項 | For research use only |
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