Mouse PADI4 Recombinant Protein (N-Strep) (MV433022)

Name: Mouse PADI4 Recombinant Protein (N-Strep)
Brand: abinScience
SKU: MV433022
Price: 211 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	MV433022
Описание	Recombinant Mouse PADI4 Protein, N-Strep (MV433022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q9Z183
Длина белка	Met1-Pro666
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Mus musculus (Mouse)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	EC:3.5.3.15, Pad4, Padi4, Pdi4, Peptidylarginine deiminase IV, Protein-arginine deiminase type IV, Protein-arginine deiminase type-4
Фон	Protein-arginine deiminase type-4 is a ~74 kDa protein. Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. 1. Cuthbert, GL. et al. (2004) Cell 118, 545-53. PMID: 15339660 2. Yang, L. et al. (2020) Nature 583, 133-138. PMID: 32528174 3. Christophorou, MA. et al. (2014) Nature 507, 104-8. PMID: 24463520 4. Li, P. et al. (2010) The Journal of experimental medicine 207, 1853-62. PMID: 20733033 5. Martinod, K. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 8674-9. PMID: 23650392
Примечание	For research use only

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Mouse PADI4 Recombinant Protein (N-Strep).pdf

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