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| カタログ番号 | MV725012 |
|---|---|
| 説明 |
Recombinant Mouse MYOC Protein, N-His (MV725012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O70624 |
| タンパク質長 | Cys231-Met490 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Myoc, Myocilin, Myocilin 20 kDa N-terminal fragment, Myocilin 35 kDa N-terminal fragment, Myocilin, C-terminal fragment, Myocilin, N-terminal fragment, Tigr, Trabecular meshwork-induced glucocorticoid response protein |
| 背景 | Myocilin is a ~55 kDa protein. Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. 1. Kwon, HS. et al. (2013) The Journal of biological chemistry 288, 16882-16894. PMID: 23629661 2. Kwon, HS. et al. (2013) The Journal of biological chemistry 288, 26357-71. PMID: 23897819 3. Joe, MK. et al. (2012) The Journal of biological chemistry 287, 13216-27. PMID: 22371502 |
| 注意事項 | For research use only |
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