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| カタログ番号 | MW398012 |
|---|---|
| 説明 |
Recombinant Mouse IL6ST Protein, N-His (MW398012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q00560 |
| タンパク質長 | Glu26-Asp213 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha, CD130, Il6st |
| 背景 | Interleukin-6 receptor subunit beta is a ~102 kDa protein. Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. 1. Saito, M. et al. (1992) Journal of immunology (Baltimore, Md. : 1950) 148, 4066-71. PMID: 1602143 2. Ohtani, T. et al. (2000) Immunity 12, 95-105. PMID: 10661409 3. Starr, R. et al. (1997) Nature 387, 917-21. PMID: 9202125 4. Taniguchi, K. et al. (2015) Nature 519, 57-62. PMID: 25731159 5. Malsch, P. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 9845-56. PMID: 25057188 6. Johnson, RW. et al. (2015) Bone 81, 343-351. PMID: 26255596 7. Yoshida, K. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 407-11. PMID: 8552649 |
| 注意事項 | For research use only |
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