Mouse STAT1 Recombinant Protein (N-His) (MW746012)

Name: Mouse STAT1 Recombinant Protein (N-His)
Brand: abinScience
SKU: MW746012
Price: 211 USD
Availability: InStock

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100ug
1mg

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Número de catálogo	MW746012
Descripción	Recombinant Mouse STAT1 Protein, N-His (MW746012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	P42225
Longitud de proteína	Met1-Asn129
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Mus musculus (Mouse)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Signal transducer and activator of transcription 1, Stat1
Fondo	Signal transducer and activator of transcription 1 is a ~87 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. 1. Hart, KC. et al. (2001) Molecular biology of the cell 12, 931-42. PMID: 11294897 2. Nair, JS. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 5971-6. PMID: 11972023 3. Krejci, P. et al. (2008) PloS one 3, e3961. PMID: 19088846 4. Perwitasari, O. et al. (2011) The Journal of biological chemistry 286, 44412-23. PMID: 22065572 5. Cirri, P. et al. (1997) Biochemical and biophysical research communications 239, 493-7. PMID: 9344858 6. He, K. et al. (2023) Cell 186, 3033-3048.e20. PMID: 37327784
Nota	For research use only

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Datasheet

Mouse STAT1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

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Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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