Mouse STAT1 Recombinant Protein (N-His) (MW746012)

Name: Mouse STAT1 Recombinant Protein (N-His)
Brand: abinScience
SKU: MW746012
Price: 211 USD
Availability: InStock

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Aperçu

Numéro de catalogue	MW746012
Description	Recombinant Mouse STAT1 Protein, N-His (MW746012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P42225
Longueur de protéine	Met1-Asn129
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Mus musculus (Mouse)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	Signal transducer and activator of transcription 1, Stat1
Contexte	Signal transducer and activator of transcription 1 is a ~87 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. 1. Hart, KC. et al. (2001) Molecular biology of the cell 12, 931-42. PMID: 11294897 2. Nair, JS. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 5971-6. PMID: 11972023 3. Krejci, P. et al. (2008) PloS one 3, e3961. PMID: 19088846 4. Perwitasari, O. et al. (2011) The Journal of biological chemistry 286, 44412-23. PMID: 22065572 5. Cirri, P. et al. (1997) Biochemical and biophysical research communications 239, 493-7. PMID: 9344858 6. He, K. et al. (2023) Cell 186, 3033-3048.e20. PMID: 37327784
Note	For research use only

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Mouse STAT1 Recombinant Protein (N-His).pdf

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