Mouse STAT1 Recombinant Protein (N-His) (MW746012)

Name: Mouse STAT1 Recombinant Protein (N-His)
Brand: abinScience
SKU: MW746012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Каталожный номер	MW746012
Описание	Recombinant Mouse STAT1 Protein, N-His (MW746012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P42225
Длина белка	Met1-Asn129
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Mus musculus (Mouse)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	Signal transducer and activator of transcription 1, Stat1
Фон	Signal transducer and activator of transcription 1 is a ~87 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. 1. Hart, KC. et al. (2001) Molecular biology of the cell 12, 931-42. PMID: 11294897 2. Nair, JS. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 5971-6. PMID: 11972023 3. Krejci, P. et al. (2008) PloS one 3, e3961. PMID: 19088846 4. Perwitasari, O. et al. (2011) The Journal of biological chemistry 286, 44412-23. PMID: 22065572 5. Cirri, P. et al. (1997) Biochemical and biophysical research communications 239, 493-7. PMID: 9344858 6. He, K. et al. (2023) Cell 186, 3033-3048.e20. PMID: 37327784
Примечание	For research use only

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Mouse STAT1 Recombinant Protein (N-His).pdf

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