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| カタログ番号 | MY149012 |
|---|---|
| 説明 |
Recombinant Mouse NMB Protein, N-His-SUMO (MY149012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9CR53 |
| タンパク質長 | Asn28-Arg78 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Neuromedin-B, Neuromedin-B-32, Nmb |
| 背景 | Neuromedin-B is a ~13 kDa protein. Stimulates smooth muscle contraction. Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity. Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem. These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneeze reflex. Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons. 1. Li, P. et al. (2016) Nature 530, 293-297. PMID: 26855425 2. Li, F. et al. (2021) Cell 184, 3762-3773.e10. PMID: 34133943 3. Ehling, S. et al. (2019) Acta dermato-venereologica 99, 587-893. PMID: 30734045 4. Yang, G. et al. (2019) Veterinary research 50, 80. PMID: 31601264 5. Yeo, CE. et al. (2017) Experimental cell research 359, 112-119. PMID: 28780306 |
| 注意事項 | For research use only |
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