Human DKK1 Recombinant Protein (Tag Free) (HF914021)

Name: Human DKK1 Recombinant Protein (Tag Free)
Brand: abinScience
SKU: HF914021
Price: 420 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD):

Спецификация:

50ug
100ug
1mg

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HF914021
Описание	Human DKK1 Recombinant Protein (Tag Free) (HF914021) expressed in Mammalian cells. Purity: >95% as determined by SDS-PAGE. by SDS-PAGE. Highlights ●Recombinant — Consistent lot-to-lot performance. ●High Purity — >95% as determined by SDS-PAGE. by SDS-PAGE for demanding downstream applications. ●Bioactive — Verified biological activity.
Система экспрессии	Mammalian cells
Номер доступа	O94907
Длина белка	Thr32-His266
Применения	ELISA, Functional assay
Виды	Homo sapiens (Human)
Биологическая активность	Measured by its ability to inhibit 50ng/ml wnta-3a induced Topflash reporter activity in CHO cells. The ED50 is ≤50ng/ml.
Характер	Recombinant
Уровень эндотоксинов	<0.01 EU/ug
Чистота	>95% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% Mannitol, 0.01% Tween 80, pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	It is recommended to redissolve in sterile deionized water.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	DKK1, Dickkopf-1, Dickkopf-related protein 1, Dkk-1, SK, hDkk-1
Фон	Dickkopf-related protein 1 (DKK1) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. 1. Ahn, VE. et al. (2011) Developmental cell 21, 862-73. PMID: 22000856 2. Niehrs, C. (2006) Oncogene 25, 7469-81. PMID: 17143291
Примечание	For research use only