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| カタログ番号 | VK130024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-AAV6 VP3/Capsid protein VP3 Polyclonal Antibody (VK130024) is a rabbit polyclonal antibody detecting Capsid protein VP1. Suitable for Adeno-associated virus - 6.
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| 種反応性 | Adeno-associated virus 6 (AAV6) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant AAV6 VP3/Capsid protein VP3 (Met203-Leu736). | ||||||||
| ターゲット | Capsid protein VP1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O56137 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Genome polyprotein (VP3/Capsid protein VP3) is a ~246 kDa protein. Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor PVR to provide virion attachment to target host epithelial cells. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis in Hela cells and through caveolin-mediated endocytosis in brain microvascular endothelial cells. 1. Hogle, JM. et al. (1985) Science (New York, N.Y.) 229, 1358-65. PMID: 2994218 2. Strauss, M. et al. (2013) Journal of virology 87, 3903-14. PMID: 23365424 3. Strauss, M. et al. (2015) Journal of virology 89, 4143-57. PMID: 25631086 4. Brandenburg, B. et al. (2007) PLoS biology 5, e183. PMID: 17622193 5. Coyne, CB. et al. (2007) The EMBO journal 26, 4016-28. PMID: 17717529 6. Bergelson, JM. (2008) Trends in microbiology 16, 44-7. PMID: 18191571 | ||||||||
| 注意事項 | For research use only. |
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