Anti-ABCB6 Polyclonal Antibody (HV027014)

Name: Anti-ABCB6 Polyclonal Antibody
Brand: abinScience
SKU: HV027014
Price: 96 USD
Availability: InStock

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Datasheet
SDS

Vista general

Número de catálogo

HV027014

Descripción

Anti-ABCB6 Polyclonal Antibody (HV027014) is a rabbit polyclonal antibody detecting ABCB6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human ABCB6 (Ile590-Arg842).

Objetivo

UMAT, ATP-binding cassette sub-family B member 6, mitochondrial, MTABC3, Mitochondrial ABC transporter 3, ABCB6, P-glycoprotein-related protein, Mt-ABC transporter 3, PRP, Ubiquitously-expressed mammalian ABC half transporter

Purificación

Purified by antigen affinity column.

Número de acceso

Q9NP58

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

ATP-binding cassette sub-family B member 6 (ABCB6) is a ~93 kDa protein. ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis.

1. Paterson, JK. et al. (2007) Biochemistry 46, 9443-52. PMID: 17661442

2. Chavan, H. et al. (2013) The Journal of biological chemistry 288, 22658-69. PMID: 23792964

3. Fukuda, Y. et al. (2016) Nature communications 7, 12353. PMID: 27507172

4. Wang, C. et al. (2020) Protein science : a publication of the Protein Society 29, 2363-2374. PMID: 33007128

5. Mitsuhashi, N. et al. (2000) The Journal of biological chemistry 275, 17536-40. PMID: 10837493

6. Krishnamurthy, PC. et al. (2006) Nature 443, 586-9. PMID: 17006453

7. Bergam, P. et al. (2018) Journal of molecular biology 430, 3802-3818. PMID: 29940187

8. Chavan, H. et al. (2011) Toxicological sciences : an official journal of the Society of Toxicology 120, 519-28. PMID: 21266531

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-ABCB6 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: HL60 cell lysate

Referencias

Datasheet

Anti-ABCB6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo