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| カタログ番号 | HV027014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ABCB6 Polyclonal Antibody (HV027014) is a rabbit polyclonal antibody detecting ABCB6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCB6 (Ile590-Arg842). | ||||||||
| ターゲット | UMAT, ATP-binding cassette sub-family B member 6, mitochondrial, MTABC3, Mitochondrial ABC transporter 3, ABCB6, P-glycoprotein-related protein, Mt-ABC transporter 3, PRP, Ubiquitously-expressed mammalian ABC half transporter | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NP58 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-binding cassette sub-family B member 6 (ABCB6) is a ~93 kDa protein. ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis. 1. Paterson, JK. et al. (2007) Biochemistry 46, 9443-52. PMID: 17661442 2. Chavan, H. et al. (2013) The Journal of biological chemistry 288, 22658-69. PMID: 23792964 3. Fukuda, Y. et al. (2016) Nature communications 7, 12353. PMID: 27507172 4. Wang, C. et al. (2020) Protein science : a publication of the Protein Society 29, 2363-2374. PMID: 33007128 5. Mitsuhashi, N. et al. (2000) The Journal of biological chemistry 275, 17536-40. PMID: 10837493 6. Krishnamurthy, PC. et al. (2006) Nature 443, 586-9. PMID: 17006453 7. Bergam, P. et al. (2018) Journal of molecular biology 430, 3802-3818. PMID: 29940187 8. Chavan, H. et al. (2011) Toxicological sciences : an official journal of the Society of Toxicology 120, 519-28. PMID: 21266531 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-ABCB6 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: HL60 cell lysate
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