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| カタログ番号 | HF952014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ABCB7 Polyclonal Antibody (HF952014) is a rabbit polyclonal antibody detecting ABCB7 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCB7 (Val472-Cys752). | ||||||||
| ターゲット | ABC transporter 7 protein, ABC7, ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABCB7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75027 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Iron-sulfur clusters transporter ABCB7, mitochondrial is a ~82 kDa protein. Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1. May also play a role in hematopoiesis. 1. Allikmets, R. et al. (1999) Human molecular genetics 8, 743-9. PMID: 10196363 2. Cavadini, P. et al. (2007) Blood 109, 3552-9. PMID: 17192393 3. Pearson, SA. et al. (2021) Archives of biochemistry and biophysics 697, 108661. PMID: 33157103 4. Maio, N. et al. (2019) Haematologica 104, 1756-1767. PMID: 30765471 | ||||||||
| 注意事項 | For research use only. |
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