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| カタログ番号 | HB262014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ABCD3 Polyclonal Antibody (HB262014) is a rabbit polyclonal antibody detecting ABCD3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCD3 (Pro425-Ser659). | ||||||||
| ターゲット | ABCD3, 70 kDa peroxisomal membrane protein, ATP-binding cassette sub-family D member 3, PXMP1, PMP70 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P28288 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-binding cassette sub-family D member 3 (ABCD3) is a ~75 kDa protein. Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. 1. Roerig, P. et al. (2001) FEBS letters 492, 66-72. PMID: 11248239 2. van Roermund, CW. et al. (2014) Biochimica et biophysica acta 1841, 563-8. PMID: 24333844 3. Ferdinandusse, S. et al. (2015) Human molecular genetics 24, 361-70. PMID: 25168382 4. Okamoto, T. et al. (2018) Biochemical and biophysical research communications 496, 1122-1127. PMID: 29397936 5. Vaca Jacome, AS. et al. (2015) Proteomics 15, 2519-24. PMID: 25944712 | ||||||||
| 注意事項 | For research use only. |
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