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| カタログ番号 | HX969014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ABCE1 Polyclonal Antibody (HX969014) is a rabbit polyclonal antibody detecting ABCE1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCE1 (Ile389-Asn556). | ||||||||
| ターゲット | HuHP68, RNS4I, RNASEL1, RNase L inhibitor, 2'-5'-oligoadenylate-binding protein, RLI, ABCE1, ATP-binding cassette sub-family E member 1, RNASELI, Ribonuclease 4 inhibitor | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P61221 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-binding cassette sub-family E member 1 (ABCE1) is a ~67 kDa protein. Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. 1. Pisarev, AV. et al. (2010) Molecular cell 37, 196-210. PMID: 20122402 2. Pisareva, VP. et al. (2011) The EMBO journal 30, 1804-17. PMID: 21448132 3. Wu, Z. et al. (2018) Cell metabolism 28, 130-144.e7. PMID: 29861391 5. Le Roy, F. et al. (2001) The Journal of biological chemistry 276, 48473-82. PMID: 11585831 | ||||||||
| 注意事項 | For research use only. |
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