

| Каталожный номер | HP927014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human ABCG4 (Val59-Thr301). | ||||||||
| Цель | ATP-binding cassette sub-family G member 4, ABCG4, WHITE2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9H172 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | ATP-binding cassette sub-family G member 4 (ABCG4) is a ~71 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment. Induces apoptosis in various cells. 1. Cserepes, J. et al. (2004) Biochemical and biophysical research communications 320, 860-7. PMID: 15240127 2. Yang, A. et al. (2021) Biochimica et biophysica acta. General subjects 1865, 129769. PMID: 33141061 3. Hegyi, Z. et al. (2016) PloS one 11, e0156516. PMID: 27228027 | ||||||||
| Примечание | For research use only. |
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